Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Dalmelitinib
Catalog No.: PC-49132Not For Human Use, Lab Use Only.
Dalmelitinib is a potent, selective c-Met tyrosine kinase inhibitor with IC50 of 0.7 nM, inhibits cell growth of gastric cells SNU5 with IC50 of 2.0 nM, binds to the ATP-binding region of c-MET kinase.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Dalmelitinib is a potent, selective c-Met tyrosine kinase inhibitor with IC50 of 0.7 nM, inhibits cell growth of gastric cells SNU5 with IC50 of 2.0 nM, binds to the ATP-binding region of c-MET kinase.
Dalmelitinib has a better inhibiting activity than SGX-523 in a dosedependent manner against different human tumor cell lines comprising human gastric (MKN-45) and human non-small cell lung (NCI-H1993).
Dalmelitinib (10, 30, 60 mg/kg) significantly inhibited the tumor (MKN-45) growth in nude mice and the inhibitory rates were 29.5%, 34.2%, and 61.4%, respectively.
| M.Wt | 461.475 | |
| Formula | C22H16FN7O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Patent CN108623619 A 2018-10-09 .
2. Junjun Zhao, et al. Bioorg Med Chem. 2016 Aug 15;24(16):3483-93.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
