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Chemical Structure : Danirixin
CAS No.: 954126-98-8
Catalog No.: PC-45710Not For Human Use, Lab Use Only.
Danirixin (GSK1325756) is a high-affinity, selective and reversible CXCR2 antagonist (IC50=12.5 nM, CXCL8.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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Danirixin (GSK1325756) is a high-affinity, selective and reversible CXCR2 antagonist (IC50=12.5 nM, CXCL8.
Danirixin (GSK1325756) blocks the CD11b upregulation with pIC50 of 6.05 and 6.3, respectively, in rat and human whole-blood studies.
Danirixin (GSK1325756) blocks the influx of neutrophils into the lung in vivo in rats following aerosol lipopolysaccharide (ED50=1.4 mg/kg); orally active.
| M.Wt | 441.9041 | |
| Formula | C19H21ClFN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 8 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)- |
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1. Bloomer JC, et al. Eur J Pharm Biopharm. 2017 Apr 3. pii: S0939-6411(16)31009-8.
2. Miller BE, et al. BMC Pharmacol Toxicol. 2015 Jun 20;16:18.
3. Busch-Petersen J, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):338-346.
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