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Chemical Structure : Danusertib
CAS No.: 827318-97-8
Catalog No.: PC-42422Not For Human Use, Lab Use Only.
Danusertib (PHA-739358) is a potent, ATP-competitive Aurora kinase inhibitor with IC50 of 13,79 and 61 nM for Aurora A, B and C, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Danusertib (PHA-739358) is a potent, ATP-competitive Aurora kinase inhibitor with IC50 of 13,79 and 61 nM for Aurora A, B and C, respectively.
Danusertib (PHA-739358) also inhibits Abl, RET, and FGFR1 (IC50=25,31, and 47 nM), efficiently inhibits imatinib-resistant Abl mutant T315I (IC50=5 nM)。
Danusertib (PHA-739358) inhibits phosphorylation of histone H3 in Ser10, and has significant antitumor activity in different xenografts and spontaneous and transgenic animal tumor models.
| M.Wt | 474.5548 | |
| Formula | C26H30N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 7.5 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-(4-methyl-1-piperazinyl)-N-[1,4,5,6-tetrahydro-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3-yl]- |
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1. Fancelli D, et al. J Med Chem. 2006 Nov 30;49(24):7247-51.
2. Modugno M, et al. Cancer Res. 2007 Sep 1;67(17):7987-90.
3. Carpinelli P, et al. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3158-68.
4. Gontarewicz A, et al. Blood. 2008 Apr 15;111(8):4355-64.
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