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Chemical Structure : Dasatinib hydrochloride
CAS No.: 854001-07-3
Catalog No.: PC-42427Not For Human Use, Lab Use Only.
A potent, orally bioavailable, dual Src/Abl kinase inhibitor with IC50 of 0.5, 0.4, 0.5 and <1 nM for Src, Lck, Yes and Bcr-Abl, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 200 mg | $52 | In stock | |
| 500 mg | $78.4 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
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A potent, orally bioavailable, dual Src/Abl kinase inhibitor with IC50 of 0.5, 0.4, 0.5 and <1 nM for Src, Lck, Yes and Bcr-Abl, respectively; exhibits two-log increased potency relative to imatinib and retains activity against 14 of 15 imatinib-resistant BCR-ABL mutants; prolongs survival of mice with BCR-ABL-driven disease and inhibits proliferation of BCR-ABL-positive bone marrow progenitor cells from patients with imatinib-sensitive and imatinib-resistant CML.
Blood Cancer
Approved
| M.Wt | 524.4665 | |
| Formula | C22H27Cl2N7O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 15 mg/mL |
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| Chemical Name/SMILES |
5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, hydrochloride (1:1) |
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1. Shah NP, et al. Science. 2004 Jul 16;305(5682):399-401.
2. Schittenhelm MM, et al. Cancer Res. 2006 Jan 1;66(1):473-81.
3. Johnson FM, et al. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6924-32.
4. Lombardo LJ, et al. J Med Chem. 2004 Dec 30;47(27):6658-61.
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