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Chemical Structure : Delanzomib
CAS No.: 847499-27-8
Catalog No.: PC-42597Not For Human Use, Lab Use Only.
A potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $184 | In stock | |
| 50 mg | $520 | In stock | |
| 100 mg | $768 | In stock |
Bulk size, bulk discount!
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A potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity; demonstrates marginal inhibition of the tryptic and peptidyl glutamyl activities of the proteosome; down-modulates the NF-kappaB activity and the expression of several NF-kappaB downstream effectors, induces apoptotic cell death in MM cells; demonstrates tumor regression in MM xenografts with favorable tumor selectivity profile.
Blood Cancer
Phase 1 Discontinued
| M.Wt | 413.2751 | |
| Formula | C21H28BN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Boronic acid, B-[(1R)-1-[[(2S,3R)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]- |
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1. Piva R, et al. Blood. 2008 Mar 1;111(5):2765-75.
2. Sanchez E, et al. Br J Haematol. 2010 Feb;148(4):569-81.
3. Seavey MM, et al. Int Immunopharmacol. 2012 Jan;12(1):257-70.
4. Berkers CR, et al. Mol Pharm. 2012 May 7;9(5):1126-35.
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