Delpazolid (LCB01-0371) is an oxazolidinone antibiotic that shows good antibacterial activity (MSSA MIC50=1 ug/mL).
Delpazolid (LCB01-0371) potently inhibits MSSA and MRSA clinical isolates with MIC of 0.5-2 and 0.5-4 ug/mL, respectively.
Delpazolid (LCB01-0371) shows more-potent protective effects (MSSA ED50=4.53 mg/kg) than Linezolid against systemic infections caused by Gram-positive and Gram-negative bacteria in mice model.
