Deltasonamide 1 | PDE6D-RAS | inhibitor Probechem Biochemicals

Chemical Structure : Deltasonamide 1

CAS No.: 2088485-33-8

Deltasonamide 1 (Deltasonamide1)

Catalog No.: PC-61153Not For Human Use, Lab Use Only.

Deltasonamide 1 is a specific small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$378	In stock
50 mg	$598	In stock
100 mg		Get quote

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Biological Activity

Deltasonamide 1 is a specific small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM.
PDE6δ/KRas inhibits PDE6δ/KRas interaction in cells with Kd of 85 nM.
PDE6δ/KRas selectively inhibits growth of KRas mutated and -dependent cells.

Physicochemical Properties

M.Wt	647.25
Formula	C30H39ClN6O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(4-chlorobenzyl)-N1-cyclopentyl-N4-((2-(methylamino)pyrimidin-4-yl)methyl)-N4-(piperidin-4-ylmethyl)benzene-1,4-disulfonamide

References

1. Martín-Gago P, et al. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428.

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Deltasonamide 1 (Deltasonamide1)

Biological Activity

Physicochemical Properties

References

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