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Deltasonamide 2

Chemical Structure : Deltasonamide 2

CAS No.: 2088485-34-9

Deltasonamide 2 (Deltasonamide2)

Catalog No.: PC-61154Not For Human Use, Lab Use Only.

Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM.
Deltasonamide 2 inhibits PDE6δ/KRas interaction in cells with Kd of 64 nM, selectively inhibits growth of KRas mutated and -dependent cells.
Deltasonamide 2 inhibits the oncogenic KRas-dependent MiaPaCa-2 with IC50 of 750 nM.

Physicochemical Properties

M.Wt 647.25
Formula C30H39ClN6O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N1-((1r,4r)-4-aminocyclohexyl)-N4-(4-chlorobenzyl)-N4-cyclopentyl-N1-((2-(methylamino)pyrimidin-4-yl)methyl)benzene-1,4-disulfonamide

References

1. Martín-Gago P, et al. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428.

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