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Chemical Structure : Derazantinib
CAS No.: 1234356-69-4
Catalog No.: PC-60038Not For Human Use, Lab Use Only.
Derazantinib (ARQ-087) is a novel potent, ATP competitive multi-kinase inhibitor with IC50 of FGFR1/2/3 with IC50 of 1.8-4.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Derazantinib (ARQ-087) is a novel potent, ATP competitive multi-kinase inhibitor with IC50 of FGFR1/2/3 with IC50 of 1.8-4.5 nM.
Derazantinib (ARQ-087) also inhibits FGFR4, Src, Abl, RET, etc. (IC50<50 nM).
Derazantinib (ARQ-087) inhibits FGFR2 auto-phosphorylation and other proteins downstream in the FGFR pathway (FRS2α, AKT, ERK), shows potent anti-proliferative effect in cell lines driven by FGFR dysregulation.
Derazantinib (ARQ-087) shows tumor growth inhibition in vivo in xenograft tumor models.
| M.Wt | 468.576 | |
| Formula | C29H29FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(6R)-6-(2-fluorophenyl)-N-(3-{2-[(2-methoxyethyl)amino]ethyl}phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine |
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1. Hall TG, et al. PLoS One. 2016 Sep 14;11(9):e0162594.
2. Yu Y, et al. Anticancer Drugs. 2017 Jun;28(5):503-513.
3. Balek L, et al. Bone. 2017 Dec;105:57-66.
4. Papadopoulos KP, et al. Br J Cancer. 2017 Nov 21;117(11):1592-1599.
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