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Chemical Structure : Dexfadrostat
CAS No.: 102676-87-9
Catalog No.: PC-73413Not For Human Use, Lab Use Only.
Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) is a potent nonsteroidal inhibitor of aldosterone synthase (CYP 11B2, steroid 18-hydroxylase), also inhibits human placental aromatase (pIC50=6.17).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $118 | In stock | |
| 100 mg | $328 | In stock | |
| 200 mg | $528 | In stock | |
| 1 g | Get quote |
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Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) is a potent nonsteroidal inhibitor of aldosterone synthase (CYP 11B2, steroid 18-hydroxylase), also inhibits human placental aromatase (pIC50=6.17).
Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) inhibits aldosterone biosynthesis and reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.
| M.Wt | 223.279 | |
| Formula | C14H13N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]- |
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1. Furet P, et al. J Med Chem. 1993;36(10):1393-1400.
2. Minnaard-Huiban M, et al. Endocrinology. 2008;149(1):28-31.
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