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Chemical Structure : Diarylpropionitrile
CAS No.: 1428-67-7
Catalog No.: PC-43041Not For Human Use, Lab Use Only.
Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand, demonstrates the neuroprotective effects against 10 0M Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand, demonstrates the neuroprotective effects against 10 0M Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture; (1-100 nM) significantly decreases neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level, downregulation of pro-apoptotic activated caspase-3 and Bax, and upregulation of anti-apoptotic Bcl-2; decreases the expression levels of IL-1β and IL-6; inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.
| M.Wt | 239.2692 | |
| Formula | C15H13NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)- |
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1. Suwanna N, et al. Neurosci Lett. 2014 Aug 22;578:44-9.
2. Khalaj AJ, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19125-30.
3. Mancuso M, et al. Cancer Lett. 2011 Sep 28;308(2):197-202.
4. Motylewska E, et al. Cancer Lett. 2009 Apr 8;276(1):68-73.
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