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Chemical Structure : Diazepinomicin
Catalog No.: PC-62205Not For Human Use, Lab Use Only.
Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation, binds the central and/or peripheral benzodiazepine receptors (PBR, TSPO).
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Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation, binds the central and/or peripheral benzodiazepine receptors (PBR, TSPO); prevents EGF-induced phosphorylation of Raf-1, MEK, and ERK1/2; reduces Ras-GTP levels and induces apoptosis; shows antitumor activity and decreases tumor Raf-1 protein levels in MIA PaCa-2 tumor-bearing mice.
Brain Cancer
Phase 2 Discontinued
| M.Wt | 462.58 | |
| Formula | C28H34N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Campbell PM, et al. J Mol Signal. 2010 Nov 2;5:18.
2. Quah SY, et al. Pharmacol Ther. 2016 Jun;162:35-57.
3. Boufaied N, et al. Anticancer Drugs. 2010 Jun;21(5):543-52.
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