Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Didemethylclomipramine
Catalog No.: PC-36045Not For Human Use, Lab Use Only.
Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine; shows growth inhibition of both Mycobacterium smegmatis and M. tuberculosis cells via inhibition of Mycobacterium tuberculosis topoisomerase I (MttopoI), inhibits DNA relaxation activity of MttopoI; shows MIC vales of 30 μM and 60 μM for M. smegmatis and M. tuberculosis, respectively.
| M.Wt | 300.83 | |
| Formula | C18H21ClN2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Godbole AA, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1549-57.
2. Ekins S, et al. Tuberculosis (Edinb). 2017 Mar;103:52-60.
3. Johnson-Davis KL, et al. Methods Mol Biol. 2012;902:175-84.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
