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Dihydroartemisinin

Chemical Structure : Dihydroartemisinin

CAS No.: 71939-50-9

Dihydroartemisinin (Artenimol, β-Dihydroartemisinin)

Catalog No.: PC-27967Not For Human Use, Lab Use Only.

Dihydroartemisinin (DHA, Artenimol, β-Dihydroartemisinin) is an antimalarial agent and semi-synthetic derivative of Artemisinin, also has anti-inflammatory and anti-cancer effect, directly binds to YTHDF2 and inhibits its function, induces autophagy by inhibiting NF-κB activation, induces iron-dependent cell death (ferroptosis) in tumor cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Dihydroartemisinin (DHA, Artenimol, β-Dihydroartemisinin) is an antimalarial agent and semi-synthetic derivative of Artemisinin, also has anti-inflammatory and anti-cancer effect, directly binds to YTHDF2 and inhibits its function, induces autophagy by inhibiting NF-κB activation, induces iron-dependent cell death (ferroptosis) in tumor cells.
Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1alpha activation in C6 glioma cells.
Dihydroartemisinin shows selective inhibition of ovarian cancer cell growth, apoptosis induction, and G2 arrest
Dihydroartemisinin promotes neurological rehabilitation after ischemic stroke by targeting TAK1-CREB1 signaling pathway to inhibit ferroptosis.
Dihydroartemisinin inhibits Epstein-Barr virus reactivation and replication targeting lytic proteins.
DHA significantly alleviated arthritis and inhibited neutrophil extracellular traps (NETs) formation both in vivo and in vitro.

Physicochemical Properties

M.Wt 284.35
Formula C15H24O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol

References

1. Lin AJ, et al. J Med Chem. 1989 Jun;32(6):1249-52.

2. Ye S, et al. Mol Immunol. 2026 Sep;197:144-157.

3. Moore JC, et al. Cancer Lett. 1995 Nov 27;98(1):83-7.

4. Ooko E, et al. Phytomedicine. 2015 Oct 15;22(11):1045-54.

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