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Chemical Structure : Diptoindonesin G
Catalog No.: PC-60204Not For Human Use, Lab Use Only.
A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells.
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A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ.
| M.Wt | 360.321 | |
| Formula | C21H12O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhao Z, et al. Chem Biol. 2015 Dec 17;22(12):1608-21.
2. Juliawaty LD, et al. Nat Prod Commun. 2009 Jul; 4(7):947-50.
3. Gao J, et al. Cell Death Dis. 2017 May 4;8(5):e2765.
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