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Chemical Structure : Dooku1
CAS No.: 2253744-54-4
Catalog No.: PC-63441Not For Human Use, Lab Use Only.
Dooku1 is a Yoda1 analogue that antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation, lacks agonist activity.
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Dooku1 is a Yoda1 analogue that antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation, lacks agonist activity.
Dooku1 inhibits 2 μM Yoda1-induced Ca2+ -entry with IC50 of 1.3 μM (HEK 293 cells) and 1.5 μM (HUVECs) yet failed to inhibit constitutive Piezo1 channel activity.
Dooku1 has no effect on endogenous ATP-evoked Ca2+ elevation or store-operated Ca2+ entry in HEK 293 cells or Ca2+ entry through TRPV4 or TRPC4 channels overexpressed in CHO and HEK 293 cells.
| M.Wt | 326.195 | |
| Formula | C13H9Cl2N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((2,6-dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole |
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1. Evans EL, et al. Br J Pharmacol. 2018 May;175(10):1744-1759.
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