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Chemical Structure : Dorzagliatin
Catalog No.: PC-60040Not For Human Use, Lab Use Only.
Dorzagliatin (HMS-5552, HMS5552) is a novel potent, fourth-generation glucokinase (GK) activator.
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Dorzagliatin (HMS-5552, HMS5552) is a novel potent, fourth-generation glucokinase (GK) activator.
HMS-5552 exerts its antidiabetic effect by inhibiting insulin resistance and increasing insulin sensitivity, significantly increased GK expression.
HMS-5552 effectively improves GK activity and insulin resistance by targeting both the liver and pancreas in rat T2DM models.
| M.Wt | 462.931 | |
| Formula | C22H27ClN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang P, et al. J Diabetes Res. 2017;2017:5812607.
2. Xu H, et al. Drug Des Devel Ther. 2016 May 9;10:1619-26.
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