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Chemical Structure : Dovitinib
CAS No.: 405169-16-6
Catalog No.: PC-45899Not For Human Use, Lab Use Only.
Dovitinib (CHIR-258, TKI258) is a multitargeted RTK inhibitor of class III, IV, and V RTKs with IC50 of 1/2/36/8/9 nM for FLT3/c-KIT/c-Fms/FGFR1/FGFR3, respectively.
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|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $68 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | Get quote |
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Dovitinib (CHIR-258, TKI258) is a multitargeted RTK inhibitor of class III, IV, and V RTKs with IC50 of 1/2/36/8/9 nM for FLT3/c-KIT/c-Fms/FGFR1/FGFR3, respectively.
Dovitinib (CHIR-258, TKI258) also inhibits VEGFR1/2/3 (IC50=10/13/8 nM) and PDGFRβ/α (IC50=27/210 nM).
Dovitinib (CHIR-258, TKI258) selectively inhibits the growth of B9 cells and human myeloma cell lines expressing wild-type (WT) or activated mutant FGFR3.
Dovitinib (CHIR-258, TKI258) inhibits downstream ERK 1/2 phosphorylation and induces cytostatic and cytotoxic effects; demonstrates activity in a xenograft mouse model of FGFR3 MM; orally active.
| M.Wt | 392.4294 | |
| Formula | C21H21FN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 25 mg/mL |
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| Chemical Name/SMILES |
2(1H)-Quinolinone, 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]- |
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1. Trudel S, et al. Blood. 2005 Apr 1;105(7):2941-8.
2. Lopes de Menezes DE, et al. Clin Cancer Res. 2005 Jul 15;11(14):5281-91.
3. Xin X, et al. Clin Cancer Res. 2006 Aug 15;12(16):4908-15.
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