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Chemical Structure : Drp1 inhibitor SC9
Catalog No.: PC-20940Not For Human Use, Lab Use Only.
Drp1 inhibitor SC9 (Drp1 SWAG ligand SC9) is a small molecule binder of dynamin-related protein 1 (Drp1) allosteric site switch I-adjacent groove (SWAG), inhibits GTPase activity of Drp1 (IC50=270 nM) and inhibits Drp1-Fis1 interaction in cells.
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Drp1 inhibitor SC9 (Drp1 SWAG ligand SC9) is a small molecule binder of dynamin-related protein 1 (Drp1) allosteric site switch I-adjacent groove (SWAG), inhibits GTPase activity of Drp1 (IC50=270 nM) and inhibits Drp1-Fis1 interaction in cells.
SC9 act as uncompetitive inhibitors of WT Drp1, SC9 (1 uM) reduced both Km and Vmax of Drp1.
SC9 reduces LPS-induced mitochondrial dysfunction in H9c2 cells.
SC9 blocks stress-induced Drp1 oligomerization, inhibits LPS-induced mitochondrial membrane depolarization in H9c2 cells with IC50 of 750 nM.
SC9 blocks mitochondrial translocation of Drp1 to the mitochondria by selectively inhibiting Drp1-Fis1 interaction.
SC9 (10 mg/kg, i.p.) effectively inhibits LPS-induced mortality in mouse model of endotoxemia.
| M.Wt | 466.52 | |
| Formula | C21H22N8O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rios L, et al. Nat Commun. 2023 Jul 19;14(1):4356.
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