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Chemical Structure : Duvelisib
CAS No.: 1201438-56-3
Catalog No.: PC-45169Not For Human Use, Lab Use Only.
Duvelisib (IPI-145, INK-1197) is a potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Duvelisib (IPI-145, INK-1197) is a potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.
Duvelisib (IPI-145, INK-1197) displays high selectivity for PI3K δ/γ than other protein kinases.
Duvelisib (IPI-145, INK-1197) exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation.
Duvelisib (IPI-145, INK-1197) exhibits potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models.
| M.Wt | 416.863 | |
| Formula | C22H17ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 41 mg/mL |
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| Chemical Name/SMILES |
1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]- |
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1. Winkler DG, et al. Chem Biol. 2013 Nov 21;20(11):1364-74.
2. Boyle DL, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):271-80.
3. Dong S, et al. Blood. 2014 Dec 4;124(24):3583-6.
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