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Chemical Structure : Dynarrestin
CAS No.: 2222768-84-3
Catalog No.: PC-62399Not For Human Use, Lab Use Only.
Dynarrestin is a novel inhibitor of cytoplasmic Dyneins 1 and 2, acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis.
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| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 100 mg | $1280 | In stock | |
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Dynarrestin is a novel inhibitor of cytoplasmic Dyneins 1 and 2, acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis; rapidly and reversibly inhibits endosome movement in living cells and perturbs mitosis by inducing spindle misorientation and pseudoprometaphase delay; reversibly inhibits cytoplasmic dynein 2-dependent intraflagellar transport (IFT) of the cargo IFT88 and flux of Smo within cilia without interfering with ciliogenesis and suppresses Hh-dependent proliferation of neuronal precursors and tumor cells.
| M.Wt | 431.502 | |
| Formula | C22H23F2N3O2S | |
| CAS No. | 2222768-84-3 | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name |
ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate |
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1. Höing S, et al. Cell Chem Biol. 2018 Jan 26. pii: S2451-9456(17)30463-4.
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