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Chemical Structure : E7046
CAS No.: 1369489-71-3
Catalog No.: PC-63545Not For Human Use, Lab Use Only.
E7046 (Palupiprant, ER-886046) is a potent, selective, orally bioavailable EP4 receptor antagonist with IC50 of 13.5 nM, Ki of 23.14 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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E7046 (Palupiprant, ER-886046) is a potent, selective, orally bioavailable EP4 receptor antagonist with IC50 of 13.5 nM, Ki of 23.14 nM.
E7046 (Palupiprant, ER-886046) displays >1,500 fold selectivity for EP4 relative to EP4 closest homolog, the PGE2 receptor EP2.
E7046 (Palupiprant, ER-886046) diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity.
E7046 (Palupiprant, ER-886046) shows anti-arthritic potential in collagen induced arthritis model.
| M.Wt | 483.395 | |
| Formula | C22H18F5N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid |
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1. Bender AT, et al. Am J Transl Res. 2013;5(1):92-102.
2. Albu DI, et al. Oncoimmunology. 2017 Jun 28;6(8):e1338239.
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