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Chemical Structure : EC-70124
Catalog No.: PC-63517Not For Human Use, Lab Use Only.
EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM).
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EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM); inhibits 7 out of 9 FLT3 mutants, also acts as a dual STAT3/NF-kB inhibitor, reverting both tumorigenic and stem cell properties in prostate cancer; inhibits AML cell proliferation and induces cell cycle arrest and apoptosis; in vivo oral treatment causes complete regression in AML tumor xenograft models, and ex vivo inhibits proliferation in AML patient blasts at biochemically relevant doses.
| M.Wt | 453.454 | |
| Formula | C26H19N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Civenni G, et al. Mol Cancer Ther. 2016 May;15(5):806-18.
2. Cuenca-López MD, et al. Oncotarget. 2015 Sep 29;6(29):27923-37.
3. Puente-Moncada N, et al.
4. Sánchez C, et al. Chem Commun (Camb). 2009 Jul 21;(27):4118-20.
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