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Chemical Structure : EDD3
CAS No.: 25279-15-6
Catalog No.: PC-60556Not For Human Use, Lab Use Only.
A novel Notch inhibitor that reduces protein expression of NOTCH1, NICD and HES1 in HEK293 cells and downregulates Notch target genes.
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EDD3 is a novel Notch inhibitor that reduces protein expression of NOTCH1, NICD and HES1 in HEK293 cells and downregulates Notch target genes.
EDD3 inhibits proliferation and induces G0/G1 cell cycle arrest of ORL-150 cells through inducing p27KIP1.
| M.Wt | 474.726 | |
| Formula | C30H50O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(8R,10R,12R,14R,17S)-12-hydroxy-17-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one |
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1. Velaithan V, et al. Invest New Drugs. 2017 Apr;35(2):166-179.
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