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Chemical Structure : EG01377
Catalog No.: PC-35129Not For Human Use, Lab Use Only.
EG01377 is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2.
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EG01377 is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2.
EG01377 demonstrates antiangiogenic, antimigratory, and antitumor effects in in vitro assays.
EG01377 blocks glioma-conditioned medium-induced increase in TGFβ production in purified Nrp1+, FoxP3+, and CD25+ populations of Tregs from mice.
| M.Wt | 586.682 | |
| Formula | C26H30N6O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Powell J, et al. J Med Chem. 2018 May 10;61(9):4135-4154.
2. Jarvis A, et al. J Med Chem. 2010 Mar 11;53(5):2215-26.
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