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EGCG

Chemical Structure : EGCG

CAS No.: 989-51-5

EGCG (Epigallocatechin-3-gallate)

Catalog No.: PC-21095Not For Human Use, Lab Use Only.

EGCG (Epigallocatechin-3-gallate) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis, inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity.

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Biological Activity

EGCG (Epigallocatechin-3-gallate) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis, inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity.
EGCG reduces D-2-HG production in HCT116-IDH1 wt/R132H cells, decreases proliferation rates of IDH1 mut cells and at high doses sensitized cancer cells to ionizing radiation.
EGCG has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma.

Physicochemical Properties

M.Wt 458.38
Formula C22H18O11
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 3,4,5-trihydroxybenzoate

References

1. De Amicis F, et al. J Cell Physiol. 2013.

2. Peeters TH, et al. Cancer Metab. 2019 May 20;7:4.

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