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EIDD-1931

Chemical Structure : EIDD-1931

CAS No.: 3258-02-4

EIDD-1931 (Beta-d-N4-hydroxycytidine, β-d-N4-hydroxycytidine, NHC)

Catalog No.: PC-72069Not For Human Use, Lab Use Only.

EIDD-1931 (Beta-d-N4-hydroxycytidine, β-d-N4-hydroxycytidine, NHC) is an active metabolite of EIDD-2801 with broad-spectrum antiviral inhibitor of SARS-CoV-2.

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Biological Activity

EIDD-1931 (Beta-d-N4-hydroxycytidine, β-d-N4-hydroxycytidine, NHC) is an active metabolite of EIDD-2801 with broad-spectrum antiviral inhibitor of SARS-CoV-2.
EIDD-1931 displays broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs with average IC50 of 0.15 μM, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir.

Physicochemical Properties

M.Wt 259.218
Formula C9H13N3O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
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Solubility

10 mM in DMOS

Chemical Name/SMILES

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one

References

1. Painter WP, et al. Antimicrob Agents Chemother. 2021 Mar 1;65(5):e02428-20.

2. Sheahan TP, et al. Sci Transl Med. 2020 Apr 29;12(541):eabb5883.

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