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Chemical Structure : ELOVL1-IN-22
Catalog No.: PC-72515Not For Human Use, Lab Use Only.
ELOVL1-IN-22 is a potent, selective, CNS-penetran inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme, reduces C26:0 VLCFA synthesis in HEK293 with EC50 of 0.4 nM.
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ELOVL1-IN-22 is a potent, selective, CNS-penetrant, orally bioavailable inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme, reduces C26:0 VLCFA synthesis in HEK293 with EC50 of 0.4 nM.
ELOVL1-IN-22 reduced C26:0 VLCFA synthesis in ALD patient fibroblasts and lymphocytes in vitro.
ELOVL1-IN-22 reduced C26:0 lysophosphatidyl choline (LPC), a subtype of VLCFA, in the blood of ATP binding cassette transporter D1 (ABCD1) KO mice, a murine model of ALD to near wild-type levels.
ELOVL1-IN-22 is a useful tool for exploring therapeutic approaches to the treatment of adrenoleukodystrophy (ALD).
| M.Wt | 377.448 | |
| Formula | C21H23N5O2 | |
| Appearance | Solid | |
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1. Michael J Boyd, et al. J Med Chem. 2021 Dec 23;64(24):17777-17794.
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