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Chemical Structure : ENMD-1068 hydrochloride
CAS No.: 2703451-51-6
Catalog No.: PC-61560Not For Human Use, Lab Use Only.
ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
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| 100 mg | Get quote |
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ENMD-1068 hydrochloride is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.
ENMD-1068 blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice, dose dependently attenuates joint inflammation.
| M.Wt | 319.87 | |
| Formula | C15H29N3O2.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N1-3-methylbutyryl-N4-6-aminohexanoyl-piperazine hydrochloride |
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1. Kelso EB, et al. J Pharmacol Exp Ther. 2006 Mar;316(3):1017-24.
2. Kelso EB, et al. Arthritis Rheum. 2007 Mar;56(3):765-71.
3. Lohman RJ, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):256-65.
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