Chemical Structure : ENX-104
CAS No.:
3112169-30-6
ENX-104
(ENX104)
Catalog No.: PC-26137Not For Human Use, Lab Use Only.
ENX-104 is a highly selective and potent dopamine D2/D3 receptor antagonist with IC50 of 1.1 nM, 0.1 nM, 2.4 nM and 15.3 nM for D2-like inhibitory dopamine receptors D2S, D2L, D3, and D4 respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ENX-104 is a highly selective and potent dopamine D2/D3 receptor antagonist with IC50 of 1.1 nM, 0.1 nM, 2.4 nM and 15.3 nM for D2-like inhibitory dopamine receptors D2S, D2L, D3, and D4 respectively.
ENX-104 displays potent binding and full antagonist activity for D2L with affinity of 0.01 nM (Ki), and 0.1 nM (IC50), also binds strongly to and displays potent antagonist activity at D2S (Ki = 0.1 nM, IC50 = 1.1 nM) and D3 (Ki = 0.2 nM, IC50 = 2.4 nM) receptors.
ENX-104 produced sustained increases in dopamine levels in the nucleus accumbens in rats.
ENX-104 enhanced reward responsiveness at low doses corresponding to approximately 10–50% D2/D3 receptor occupancy.
Physicochemical Properties
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M.Wt
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392.94
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Formula
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C21H21D5ClN3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-chloro-2-methoxy-N-((2S,3S)-2-methyl-1-(phenylmethyl-d2)pyrrolidin-3-yl)-4-((methyl-d3)amino)benzamide
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References
1. Vadodaria KC, et al. Neuropsychopharmacology. 2025 Dec 7. doi: 10.1038/s41386-025-02287-w.
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