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Chemical Structure : EPM35
Catalog No.: PC-21349Not For Human Use, Lab Use Only.
EPM35 (Efflux pump modulator 35) is a small molecule that bind AcrB (KD=0.29 uM), inhibit AcrAB-TolC and modulates bacterial efflux pump activity, reduces bacterial intracellular load.
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EPM35 (Efflux pump modulator 35) is a small molecule that bind AcrB (KD=0.29 uM), inhibit AcrAB-TolC and modulates bacterial efflux pump activity, reduces bacterial intracellular load.
EPM35 disrupts the growth of a Gram-negative human pathogen, Salmonella enterica serotype Typhimurium (S. Typhimurium), in macrophages.
EPM35 shows little effect on bacterial growth in standard microbiological media.
EPM35 prevents energy-dependent efflux pump activity in Salmonella and bound the AcrB subunit of the AcrAB-TolC efflux system with KDs in the micromolar range.
EPM35 could disrupt infection by specifically interfering with the export of bacterial toxic metabolites, host defense factors, and/or antibiotics.
EPM35 display antibacterial synergy with antimicrobial peptides, a class of host innate immune defense molecules present in body fluids and cells.
EPM35 also has synergistic activity with antibiotics exported by AcrAB-TolC in broth and in macrophages and inhibits efflux pump activity in MDR Gram-negative ESKAPE clinical isolates.
| M.Wt | 465.30 | |
| Formula | C19H21Cl2F3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Abigail L Reens, et al. PLoS Pathog. 2018 Jun 7;14(6):e1007115.
2. Samual C Allgood, et al. mBio. 2023 Nov 3:e0249223.
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