Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ER-000444793
CAS No.: 792957-74-5
Catalog No.: PC-62132Not For Human Use, Lab Use Only.
ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM.
ER-000444793 neither affects cyclophilin D (CypD) enzymatic activity, nor displaces CsA from CypD protein.
ER-000444793 improves mitochondrial Ca2+ tolerance with IC50 of 1.2 uM, increases mitochondrial Ca2+ retention capacity dose-dependently, and delays the onset of mPT in HeLa S3 cells with no effect on mitochondrial or cellular health.
| M.Wt | 354.409 | |
| Formula | C23H18N2O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,2-Dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-4-quinolinecarboxamide |
|
1. Briston T, et al. Sci Rep. 2016 Nov 25;6:37798.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
