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Chemical Structure : ERB-041
CAS No.: 524684-52-4
Catalog No.: PC-21730Not For Human Use, Lab Use Only.
Prinaberel (ERB-041) is a potent, selective estrogen receptor beta (ERβ) agonist with IC50 of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $218 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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Prinaberel (ERB-041) is a potent, selective estrogen receptor beta (ERβ) agonist with IC50 of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively.
Prinaberel (ERB-041) displays >200-fold selectivity for ERβ over ERα. induces cell differentiation, cell cycle arrest and reduces colony formation in human SCC cells.
Prinaberel (ERB-041) reduces the expression of inflammation regulatory proteins such as p-NFκBp65, iNOS and COX-2 in A431 cells.
Prinaberel (ERB-041) promotes ovarian cancer (SKOV-3 cells) apoptosis, inhibits cell proliferation.
Prinaberel (ERB-041) suppresses development of squamous cell carcinoma in SKH-1 hairless mice, suppresses pro-inflammatory signaling pathway in UVB-induced skin tumors.
| M.Wt | 271.25 | |
| Formula | C15H10FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3-Fluoro-4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol |
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1. Malamas MS, et al. J Med Chem. 2004;47(21):5021-5040.
2. Chaudhary SC, et al. Cancer Prev Res (Phila). 2014;7(2):186-198.
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