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Chemical Structure : ERW1041E
Catalog No.: PC-21656Not For Human Use, Lab Use Only.
ERW1041E is a specific, irreversible small molecule transglutaminase 2 (TGase 2; TG2) inhibitor with Ki of 11 uM.
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ERW1041E is a specific, irreversible small molecule transglutaminase 2 (TGase 2; TG2) inhibitor with Ki of 11 uM.
ERW1041E attenuated left ventricular diastolic dysfunction and reduced cardiomyocyte hypertrophy and interstitial fibrosis in the pressure-overloaded heart, without affecting chamber dimensions and ejection fraction.
ERW1041E significantly reduced hypoxia-induced cross-linking activity and synthesis of collagen 1 and α-smooth muscle actin in both the in vivo and in vitro studies.
| M.Wt | 461.32 | |
| Formula | C20H21BrN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dafik L, et al. PLoS One. 2012;7(2):e30642.
2. Penumatsa KC, et al. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L752-L762.
3. R Edward Watts, et al. J Med Chem. 2006 Dec 14;49(25):7493-501.
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