Catalog No.: PC-23269Not For Human Use, Lab Use Only.
EU1622-240 is a positive allosteric modulator of NMDA receptors (NMDARs), preferentially potentiate GluN2B-, GluN2C-, and GluN2D-containing NMDARs with EC50 of 0.57 uM, 0.82 uM and 1.1 uM respectively.
EU1622-240 is a positive allosteric modulator of NMDA receptors (NMDARs), preferentially potentiate GluN2B-, GluN2C-, and GluN2D-containing NMDARs with EC50 of 0.57 uM, 0.82 uM and 1.1 uM respectively.
EU1622-240 enhances current response to saturating agonist (doubling response amplitude at 0.2-0.5 µM).
EU1622-240-bound NMDARs channels activated by a single agonist (glutamate or glycine) open to a unique conductance level with different pore properties and Mg2+ sensitivity, in contrast to channels arising from activation of NMDARs with both co-agonists bound.
1. Elijah Z Ullman, et al. Mol Pharmacol. 2024 Oct 23:MOLPHARM-AR-2024-001019.
2. Fritzemeier RG, et al. J Med Chem. 2025 Apr 20. doi: 10.1021/acs.jmedchem.4c02912.
