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Chemical Structure : EVP4593
CAS No.: 545380-34-5
Catalog No.: PC-20991Not For Human Use, Lab Use Only.
EVP4593 (EVP-4593) is an inhibitor of PMA/PHA-induced NF-κB pathway activation with IC50 of 9 nM, inhibits storeoperated calcium (Ca2+) entry (SOC) pathway in huntington's disease (HD) neurons.
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|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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EVP4593 (EVP-4593, QNZ) is an inhibitor of PMA/PHA-induced NF-κB pathway activation with IC50 of 9 nM, inhibits storeoperated calcium (Ca2+) entry (SOC) pathway in huntington's disease (HD) neurons.
EVP4593 inhibits store-operated Ca2+ entry in HD striatal neurons.
EVP4593 inhibits TRPC1-supported SOC Ca2+ currents in neuronal cells. protect YAC128 MSNs from glutamate-induced apoptosis.
EVP4593 reduces synaptic nSOC and rescues spine loss in YAC128 MSNs, intraventricular delivery of EVP4593 in YAC128 mice rescued age-dependent striatal spine loss in vivo.
| M.Wt | 356.43 | |
| Formula | C22H20N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
NC1=CC2=C(NCCC3=CC=C(OC4=CC=CC=C4)C=C3)N=CN=C2C=C1 |
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1. Wu J, et al. Chem Biol. 2011 Jun 24;18(6):777-93.
2. Tobe M, et al. Bioorg Med Chem. 2003b;11:3869–3878.
3. Wu J, et al. J Neurosci. 2016 Jan 6;36(1):125-41.
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