Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : EW-7197
CAS No.: 1352608-82-2
Catalog No.: PC-45749Not For Human Use, Lab Use Only.
EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-β type I receptor kinase (ALK5) with IC50 of 11 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-β type I receptor kinase (ALK5) with IC50 of 11 nM.
EW-7197 (Vactosertib, TEW-7197) also inhibits ALK4 (IC50=13 nM) and shows less potency for p38α (IC50=280 nM).
EW-7197 (Vactosertib, TEW-7197) exhibits no inhibition on ALK1/2/3/6 (>10 uM).
EW-7197 (Vactosertib, TEW-7197) inhibits Smad/TGFβ signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice.
EW-7197 (Vactosertib, TEW-7197) shows oral bioavailability (Hcl salt).
| M.Wt | 399.4236 | |
| Formula | C22H18FN7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1H-Imidazole-2-methanamine,N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl- |
|
1. Jin CH, et al. J Med Chem. 2014 May 22;57(10):4213-38.
2. Son JY, et al. Mol Cancer Ther. 2014 Jul;13(7):1704-16.
3. Yoon JH, et al. EMBO Mol Med. 2013 Nov;5(11):1720-39.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
