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Chemical Structure : Ebselen
CAS No.: 60940-34-3
Catalog No.: PC-20690Not For Human Use, Lab Use Only.
Ebselen (CCG-39161, PI-1005) is a potent voltage-dependent calcium channel (VDCC) blocker, also potently inhibits SARS CoV-2 Mpro with IC50 of 0.67 μM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $128 | In stock | |
| 100 mg | $188 | In stock | |
| 200 mg | $298 | In stock | |
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| 5 g | Get quote |
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Ebselen (CCG-39161, PI-1005) is a potent voltage-dependent calcium channel (VDCC) blocker, also potently inhibits SARS CoV-2 Mpro with IC50 of 0.67 μM.
Ebsele covalently binds to C145 of the catalytic SARS CoV-2 Mpro, shows strong antiviral effects at a concentration of 10 μM in COVID-19 virus infected Vero cells.
Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process.
Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic, renal cancer cell lines.
Ebselen also is a first-in-class inhibitor of the YTHDF m6A-binding domain, engages YTHDF proteins within cells, interfering with their mRNA binding.
| M.Wt | 274.18 | |
| Formula | C13H9NOSe | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-phenylbenzo[d][1,2]selenazol-3(2H)-one |
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1. Liang Q, et al.et al. Front Neurosci. 2019 Oct 14;13:1073.
2. Micaelli M, et al. ACS Pharmacol Transl Sci. 2022 Sep 14;5(10):872-891.
3. Jin Z, et al. et al. Nature. 2020 Apr 9.
4. Hanavan PD, et al. Oncotarget. 2015 Jul 30;6(21):18418-28.
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