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Chemical Structure : Ecopladib
Catalog No.: PC-61844Not For Human Use, Lab Use Only.
Ecopladib (PLA 725) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 0.15 and 0.11 uM in GLU micelle and rat whole blood assays, respectively.
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Ecopladib (PLA 725) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 0.15 and 0.11 uM in GLU micelle and rat whole blood assays, respectively.
Ecopladib (PLA 725) displays no activity toward the closely related β and γ isoforms, and the unrelated type II sPLA2.
Ecopladib (PLA 725) inhibits PAF production and both prostaglandin and leukotriene pathways.
Ecopladib (PLA 725) demonstrates oral efficacy in the rat carrageenan air pouch (ED50=8mg/kg) and rat carrageenan-induced paw edema (EC50=40mg/kg) models.
| M.Wt | 748.112 | |
| Formula | C39H33Cl3N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lee KL, et al. J Med Chem. 2007 Mar 22;50(6):1380-400.
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