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Edicotinib

Chemical Structure Edicotinib

CAS No.: 1142363-52-7

Edicotinib (JNJ 40346527;PRV 6527)

Catalog No.: PC-61373Not For Human Use, Lab Use Only.

Edicotinib (JNJ 40346527, PRV 6527) is a potent, selective, orally bioavailable CSF-1R inhibitor with IC50 of 3.2 nM.

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5 mg $178 In stock
25 mg $398 In stock
100 mg $1280 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Edicotinib (JNJ 40346527, PRV 6527) is a potent, selective, orally bioavailable CSF-1R inhibitor with IC50 of 3.2 nM; shows weak affinity for KIT and FLT3 (IC50= 20 nM and 190 nM, respectively); reduces the levels of EMT-associated genes, stem cell markers and chemoresistance genes, produces strong chemo-sensitizing effects in vitro and in vivo.

Rheumatoid Arthritis

Phase 2 Clinical

Physicochemical Properties

M.Wt 461.61
Formula C27H35N5O2
CAS No. 1142363-52-7
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide

Clinical Information

References

1. von Tresckow B, et al. Clin Cancer Res. 2015 Apr 15;21(8):1843-50.

2. Genovese MC, et al. J Rheumatol. 2015 Oct;42(10):1752-60.

3. Pass HI, et al. Oncotarget. 2016 Aug 30;7(35):56408-56421.

4. Kumar V, et al. Cancer Cell. 2017 Nov 13;32(5):654-668.e5.

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