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Chemical Structure : Efavirenz
CAS No.: 154598-52-4
Catalog No.: PC-42660Not For Human Use, Lab Use Only.
Efavirenz (DMP 266, EFV) is a highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $138 | In stock | |
| 100 mg | $218 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Efavirenz (DMP 266, EFV) is a highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT.
Efavirenz (DMP 266, EFV) inhibits HIV-1 replicative spread in cell culture with IC95 of 1.5 nM.
Efavirenz (DMP 266, EFV) exhibits activity against a panel of NNRTI-resistant mutant viruses.
Efavirenz (DMP 266, EFV) possesses good oral bioavailability and pharmacokinetics.
Efavirenz (DMP 266, EFV) induces autophagy and mitochondrial changes in neurons.
| M.Wt | 315.675 | |
| Formula | C14H9ClF3NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 38 mg/mL |
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| Chemical Name/SMILES |
2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)- |
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1. Young SD, et al. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5.
2. Purnell PR, et al. J Pharmacol Exp Ther. 2014 Nov;351(2):250-8.
3. Bertrand L, et al. Mol Pharmacol. 2015 Aug;88(2):304-15.
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