Efgartigimod | Anti-FcRn | Probechem Biochemicals

Chemical Structure : Efgartigimod

CAS No.: 1821402-21-4

Efgartigimod (ARGX-113, ARGX113)

Catalog No.: PC-26842Not For Human Use, Lab Use Only.

Efgartigimod (ARGX-113) is a human IgG1–derived (hIgG1-derived) Fc fragment (residues D220-K447) neonatal Fc receptor (FcRn) antagonist.

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Biological Activity

Efgartigimod (ARGX-113) is a human IgG1–derived (hIgG1-derived) Fc fragment (residues D220-K447) neonatal Fc receptor (FcRn) antagonist.
Efgartigimod has equilibrium dissociation constants for human FcRn of 14.2 nM and 320 nM at pH 6.0 and pH 7.4, respectively.
Efgartigimod induces specific, profound, and sustained reduction of serum IgG levels.

Physicochemical Properties

M.Wt
Formula	51.28 kDa
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

1. Ulrichts P, et al. J Clin Invest. 2018 Oct 1;128(10):4372-4386.

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Efgartigimod (ARGX-113, ARGX113)

Biological Activity

Physicochemical Properties

References

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