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Chemical Structure : Efipladib
Catalog No.: PC-61845Not For Human Use, Lab Use Only.
Efipladib (PLA 902) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 20 nM for LTB4 inhibition.
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Efipladib (PLA 902) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 20 nM for LTB4 inhibition.
Efipladib (PLA 902) shows efficacy in multiple acute and chronic prostaglandin and leukotriene dependent in vivo models.
Efipladib (PLA 902) also decreases basal and EGF-stimulated AKT phosphorylation and proliferation in HT-29 cancer cells, reduces xenograft growth by >90% with a concomitant decrease in AKT phosphorylation in mice (10 mg/kg, i.p. daily, >14 days).
| M.Wt | 746.14 | |
| Formula | C40H35Cl3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McKew JC, et al. J Med Chem. 2008 Jun 26;51(12):3388-413.
2. Nickerson-Nutter CL, et al. Neuropharmacology. 2011 Mar;60(4):633-41.
3. Zheng Z, et al. Oncotarget. 2014 Dec 15;5(23):12304-16.
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