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Chemical Structure : Elaiophylin
CAS No.: 37318-06-2
Catalog No.: PC-63057Not For Human Use, Lab Use Only.
Elaiophylin (Gopalamicin;Salbomycin;Azalomycin B) is a macrodiolide antibiotic and autophagy inhibitor that promotes autophagosome accumulation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $328 | In stock | |
| 2 mg | $528 | In stock | |
| 5 mg | $858 | In stock | |
| 10 mg | Get quote |
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Elaiophylin (Gopalamicin;Salbomycin;Azalomycin B) is a macrodiolide antibiotic that shows in vitro anti-protozoal activity against both Plasmodium and Trypanosoma (IC50=370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50=870 ng/ml).
Elaiophylin also is a novel autophagy inhibitor that promotes autophagosome accumulation but blocks autophagic flux by attenuating lysosomal cathepsin activity, resulting in the accumulation of SQSTM1/p62 in various cell lines.
| M.Wt | 1025.3 | |
| Formula | C54H88O18 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3E,5E,7S,8S,11E,13E,15S,16S)-8,16-bis[(2S,3R,4S)-4-[(2R,4R,5R,6R)-4-[(2R,4S,5S,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-2-hydroxy-6-methyloxan-2-yl]-3-hydroxypentan-2-yl]-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,13-tetraene-2,10-dione |
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1. Otoguro K, et al. J Antibiot (Tokyo). 2010 May;63(5):275-7.
2. Zhao X, et al. Autophagy. 2015;11(10):1849-63.
3. Wang G, et al. Cancer Biol Ther. 2017 Jul 18:1-12.
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