Chemical Structure : Enoxacin
CAS No.:
74011-58-8
Enoxacin
(AT-2266, CI-919)
Catalog No.: PC-23990Not For Human Use, Lab Use Only.
Enoxacin (Enoxacin sesquihydrate) is a fluoroquinolone antibiotic, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml).
Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs.
Enoxacin shows potent activities against gram-positive and -negative bacteria.
Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bi
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Enoxacin (Enoxacin sesquihydrate) is a fluoroquinolone antibiotic, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml).
Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs.
Enoxacin shows potent activities against gram-positive and -negative bacteria.
Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing.
Physicochemical Properties
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M.Wt
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320.32
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Formula
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C15H17FN4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
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References
1. Ge Shan, et al. Nat Biotechnol. 2008 Aug;26(8):933-40.
2. Sonia Melo, et al. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4394-9.
3. M Takei, et al. Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7.
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