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Ercalcitriol

Chemical Structure : Ercalcitriol

CAS No.: 60133-18-8

Ercalcitriol (1,25-Dihydroxyvitamin D2;1,25-Dihydroxycalciferol)

Catalog No.: PC-45808Not For Human Use, Lab Use Only.

The active circulating metabolite of vitamin D2 that binds to nuclear receptor VDR.

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5 mg $352 In stock
10 mg $632 In stock
25 mg $1328 In stock

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

The active circulating metabolite of vitamin D2 that binds to nuclear receptor VDR; activates VDR to interact with retinoid X receptor (RXR) and forms the VDR/RXR/cofactor complex, which binds to Vitamin D response elements in the promoter region of target genes to regulate gene transcription.

Physicochemical Properties

M.Wt 428.6472
Formula C28H44O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-

References

1. Nakane M, et al. J Steroid Biochem Mol Biol. 2006 Jan;98(1):72-7.

2. Hollis BW. Nutr Rev. 2007 Aug;65(8 Pt 2):S87-90.

3. Hollis BW, et al. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):473-6.

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