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Chemical Structure : Estrone sulfamate
Catalog No.: PC-61435Not For Human Use, Lab Use Only.
A potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells.
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A potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells; inhibits tissue E1-STS activity in rats by more than 95% at 10 mg/kg; exhibits potential applications in the treatment of ER-positive breast cancer and certain other conditions.
| M.Wt | 349.44 | |
| Formula | C18H23NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Purohit A, et al. J Steroid Biochem Mol Biol. 1994 Jul;50(1-2):101-4.
2. Woo LW, et al. J Med Chem. 1998 Mar 26;41(7):1068-83.
3. Woo LL, et al. Chem Biol. 2000 Oct;7(10):773-91.
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