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Chemical Structure : Etrasimod
CAS No.: 1206123-37-6
Catalog No.: PC-43209Not For Human Use, Lab Use Only.
Etrasimod (APD334) is a potent, selective, centrally available S1P1 receptor antagonist with β-arrestin EC50 of 6.1 nM, internalizes human S1P1 in CHO cells expressing HA tagged S1P1 with IC50 of 1.88 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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Etrasimod (APD334) is a potent, selective, centrally available S1P1 receptor antagonist with β-arrestin EC50 of 6.1 nM, internalizes human S1P1 in CHO cells expressing HA tagged S1P1 with IC50 of 1.88 nM.
Etrasimod (APD334) produces robust lymphocyte lowering effect (IC50=0.1 uM in mice), shows effectivity in mouse experimental autoimmune encephalomyelitis (EAE) model of MS and a rat collagen induced arthritis (CIA) model, orally active.
| M.Wt | 457.4847 | |
| Formula | C26H26F3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
Cyclopent[b]indole-3-acetic acid, 7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydro-, (3R)- |
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1. Buzard DJ, et al. ACS Med Chem Lett. 2014 Nov 4;5(12):1313-7.
2. Peyrin-Biroulet L, et al. Autoimmun Rev. 2017 May;16(5):495-503.
3. Nielsen OH, et al. Expert Opin Investig Drugs. 2016 Jun;25(6):709-18.
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