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Chemical Structure : Ezetimibe
CAS No.: 163222-33-1
Catalog No.: PC-45198Not For Human Use, Lab Use Only.
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $198 | In stock | |
| 200 mg | $298 | In stock | |
| 1 g | Get quote |
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Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules.
Ezetimibe significantly reduces plasma levels of total and low density lipoprotein cholesterol (LDL-C) both in vitro and in vivo.
Ezetimibe also is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Ezetimibe increases autophagic flux, improves hepatic steatosis in obese and diabetic rats.
| M.Wt | 409.4252 | |
| Formula | C24H21F2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)- |
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1. Pirillo A, et al. Curr Med Chem. 2016;23(10):983-99.
2. Chang E, et al. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.
3. Lee DH, et al. Free Radic Biol Med. 2016 Oct;99:520-532.
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