Chemical Structure : F389-0736
CAS No.:
1114885-86-7
F389-0736
Catalog No.: PC-28611Not For Human Use, Lab Use Only.
F389-0736 is a potent, selective and effective MAP4K4 inhibitor with IC50 of 44 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
F389-0736 is a potent, selective and effective MAP4K4 inhibitor with IC50 of 44 nM.
F389-0736 shows negligible inhibition of MAP4K1, PAK4, and STK24, with limited off-target kinase inhibition across the tested panel.
F389-0736 engages MAP4K4 and suppresses downstream signalling in pancreatic cancer cells.
F389-0736 suppresses TAK1, JNK, and p38 phosphorylation and significantly reduces cell viability and proliferation, with IC50 and GI50 values of 4.41-4.65 μM and 4.03-5.12 μM, respectively.
F389-0736 induces Sub-G1 accumulation and apoptotic signalling.
F389-0736 induces tumour-cell-intrinsic inflammatory activation, suppresses tumour-associated gene programs, perturbs survival and metabolic signalling, and enriches multiple programmed cell death-associated pathways.
Physicochemical Properties
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M.Wt
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454.96
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Formula
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C24H27ClN4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-2-(3-chlorobenzylidene)-N-(2-(4-ethylpiperazin-1-yl)ethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxamide
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References
1. Yi-Wen Wu, et al. J Enzyme Inhib Med Chem. 2026 Dec;41(1):2743434.
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